Peer-reviewed papers

Peer-reviewed papers

1. Balfour Lynn IM, Valman HB, Silverman M, Webster ADB. Nasal IgA response in wheezy infants. Arch Dis Child 1993;68:472 76.

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2. Balfour-Lynn IM, Valman HB, Wellings R, Webster ADB, Taylor GW, Silverman M. Tumour necrosis factor-alpha and leukotriene E4 production in wheezy infants. Clin Exp Allergy 1994;24:121-26. Print paper.

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3. Balfour-Lynn IM, Girdhar DR, Aitken C. Diagnosing respiratory syncytial virus by nasal lavage. Arch Dis Child 1995;72:58-59. Print paper.

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4. Balfour-Lynn IM, Madge S, Dinwiddie R. Testing carrier status in siblings of patients with cystic fibrosis. Arch Dis Child 1995;72:167-168. Print paper.

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5. Balfour-Lynn IM, Tasker RC. Futility and death in paediatric medical intensive care. J Med Ethics 1996;22:279-81. Print paper.

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6. Balfour-Lynn IM, Laverty A, Dinwiddie R. Reduced nitric oxide levels in upper airways of children with cystic fibrosis. Arch Dis Child 1996;75:319-22. Print paper.

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7. Balfour-Lynn IM, Martin I, Whitehead BF, Rees PG, Elliott MJ, de Leval MR. Heart-lung transplantation for patients under 10 with cystic fibrosis. Arch Dis Child 1997;76:38-40. Print paper.

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8. Balfour-Lynn IM, Ryley HC, Whitehead BF. Subdural empyema due to Burkholderia cepacia: an unusual complication after heart-lung transplantation for cystic fibrosis. J Roy Soc Med 1997;90 (suppl.31):59-64.

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9. Balfour-Lynn IM, Klein NJ, Dinwiddie R. Randomised controlled trial of inhaled corticosteroids (fluticasone propionate) in cystic fibrosis. Arch Dis Child 1997;77:124-30.

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10. Balfour-Lynn IM, Prasad SA, Laverty A, Whitehead BF, Dinwiddie R. A step in the right direction: assessing exercise tolerance in cystic fibrosis. Ped Pulmonol 1998;25:278-84.

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11. O’Donnell DR, McGarvey MJ, Tully JM, Balfour-Lynn IM, Openshaw PJM. Respiratory syncytial virus RNA in cells from the peripheral blood during acute infection. J Pediatr 1998;133:272-74.

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12. Dezateux C, Walters S, Balfour-Lynn IM. Inhaled corticosteroids for cystic fibrosis. (Cochrane Review). In: The Cochrane Library, Issue 1, 2000. Oxford: Update Software.

13. Wyatt HA, Sampson AP, Balfour-Lynn IM, Price JF. Production of the potent neutrophil chemokine, growth-related protein alpha (GROaplha) in cystic fibrosis children. Resp Med 2000;94:106-11.

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14. Prasad SA, Randall SD, Balfour-Lynn IM. Fifteen-count breathlessness score: an objective measure for children. Ped Pulmonol 2000;30:556-62.

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15. Cunningham S, Prasad A, Collyer L, Carr S, Balfour-Lynn I, Wallis C. Bronchoconstriction following nebulised colistin in cystic fibrosis. Arch Dis Child 2001;84:432-33.

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16. Pike SE, Prasad SA, Balfour-Lynn IM. Effect of intravenous antibiotics on exercise tolerance (3-minute step test) in cystic fibrosis. Ped Pulmonol 2001;32:38-43

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17. Aurora P, Prasad SA, Balfour-Lynn IM, Slade G, Whitehead B, Dinwiddie R. Exercise tolerance in children with cystic fibrosis undergoing lung transplantation assessment. Eur Resp J 2001 18:293-297.

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18. Ranganathan SC, Dezateux C, Bush A, Carr SB, Castle RA, Madge S, Price J, Stroobant J, Wade A, Wallis C, Stocks J, for the London Collaborative CF Group. Airway function in infants newly diagnosed with cystic fibrosis. Lancet 2001;358:1964-65.

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19. Thomson A, Hull J, Kumar R, Wallis C, Balfour-Lynn IM, on behalf of the British Paediatric Respiratory Society Empyema Study Group. A randomised trial of intrapeural urokinase in the treatment of childhood empyema. Thorax 2002;57:343-347.

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20. Payne DNR, Balfour-Lynn IM, Biggart EA, Bush A, Rosenthal M. Subcutaneous terbutaline in children with chronic severe asthma. Pediatr Pulmonol 2002;33:356-361.

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21. McShane D, Nicholson AG, Goldstraw P, Ladas G, Travis WD, Ramanan R, Balfour-Lynn IM, Rosenthal M, Bush A. Inflammatory endobronchial polyps in childhood: clinical spectrum and possible link to mechanical ventilation. Pediatr Pulmonol 2002;34:79-84.

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22. Equi A, Balfour-Lynn IM, Bush A, Rosenthal M. Long term azithromycin in children with cystic fibrosis: a double blind placebo controlled crossover trial. Lancet 2002;360:978-984

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23. Jaffe A, Buchdahl R, Bush A, Balfour-Lynn IM. Are annual blood tests in preschool cystic fibrosis patients worthwhile? Arch Dis Child 2002;87:518-521.

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24. Narang I, Pike S, Rosenthal M, Balfour-Lynn IM, Bush A. Three-minute step test to assess exercise capacity in children with cystic fibrosis with mild lung disease. Pediatr Pulmonol 2003;35:108-13.

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25. Chavasse R, Johnson P, Francis J, Balfour-Lynn I, Rosenthal M, Bush A. To clip or not to clip? Noseclips for spirometry. Eur Respir J 2003;21:876-8.

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26. Balfour-Lynn IM, Mohan U, Bush A, Rosenthal M. Intravenous immunoglobulin for cystic fibrosis lung disease: a case series of 16 children. Arch Dis Child 2004;89:315-9.

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27. Chavasse RJ, Francis J, Balfour-Lynn I, Rosenthal M, Bush A. Serum vitamin D levels in children with cystic fibrosis.

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28. Balfour-Lynn I, Walters S, Dezateux C. Inhaled corticosteroids for cystic fibrosis (Cochrane Review). In: The Cochrane Library, Issue 3, 2004. Chichester, UK: John Wiley & Sons, Ltd. Updated Feb 2004.

29. Balfour-Lynn IM, Abrahamson A, Cohen G, Hartley J, King S, Parikh D, Spencer D, Thomson AH, Urquhart D, on behalf of the Paediatric Pleural Diseases Subcommittee of the BTS Standards of Care Committee. BTS Guidelines for the management of pleural infection in children. Thorax 2005;60(Suppl 1):i1-21.

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30. Balfour-Lynn IM, Malbon K, Burman JF, Davidson SJ. Thrombophilia in children with cystic fibrosis. Pediatr Pulmonol 2005;39:306-10.

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31. Bilolikar H, Rodriguez Nam A, Rosenthal R, Henderson DC, Balfour-Lynn IM. Tumour necrosis factor gene polymorphisms and childhood wheezing. Eur Resp J 2005;26:637-646.

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32. Callaghan BD, Hoo AF, Dinwiddie R, Balfour-Lynn IM, Carr SB. Growth and lung function in Asian patients with cystic fibrosis. Arch Dis Child 2005;90:1029-1032.

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33. Hilliard T, Edwards S, Buchdahl R, Francis J, Rosenthal M, Balfour-Lynn I, Bush A, Davies J. Voriconazole therapy in children with cystic fibrosis. J Cyst Fibros 2005;4:215-20.

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34. Aurora P, Bush A, Gustafsson P, Oliver C, Wallis C, Price J, Stroobant J, Carr S, Stocks J; London Cystic Fibrosis Collaboration*. Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis. Am J Respir Crit Care Med 2005;171:249-56. * I am member of LCFC.

35. Saglani S, Nicholson AG, Scallan M, Balfour-Lynn I, Rosenthal M, Payne DN, Bush A. Investigation of young children with severe recurrent wheeze: any clinical benefit? Eur Respir J 2006;27:29-35. Print paper.

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36. Balfour-Lynn IM, Lees B, Hall P, Phillips G, Khan M, Flather M, Elborn JS, on behalf of the CF WISE (Withdrawal of Inhaled Steroids Evaluation) Investigators. Multicenter randomized controlled trial of withdrawal of inhaled corticosteroids in cystic fibrosis. Am J Resp Crit Care Med 2006;173:1356-62.

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37. Prasad SA, Balfour-Lynn IM, Carr SB, Madge SL. A comparison of the prevalence of urinary incontinence in girls with cystic fibrosis, asthma and healthy controls. Pediatr Pulmonol 2006;41:1065-8.

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38. Minasian CC, Sriskandan S, Balfour-Lynn IM, Bush A. Cystic fibrosis presenting with haematological abnormalities. Clin Lab Haematol 2006;28:423-6.

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39. Mukherjee S, Langroudi B, Rosenthal M, Balfour-Lynn IM. Incidence and outcome of scoliosis in children with pleural infection. Pediatr Pulmonol 2007;42:221-4.

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40. Regamey N, Hilliard TN, Saglani S, Zhu J, Scallan M, Balfour-Lynn IM, Rosenthal M, Jeffery PK, Alton EWFW, Bush A, Davies JC. Quality, size and composition of paediatric endobronchial biopsies in cystic fibrosis. Chest 2007;131:1710-7.

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41. Lum S, Gustafsson P, Ljungberg H, Hülskamp G, Bush A, Carr SB, Castle R, Hoo AF, Price J, Ranganathan S, Stroobant J, Wade A, Wallis C, Wyatt H, Stocks J; London Cystic Fibrosis Collaboration*. Early detection of cystic fibrosis lung disease: multiple-breath washout versus raised volume tests. Thorax. 2007;62:341-7. * I am member of LCFC.

42. Hilliard TN, Sukhani S, Francis J, Madden N, Rosenthal M, Balfour-Lynn I, Bush A, Davies J. Bronchoscopy following diagnosis with cystic fibrosis. Arch Dis Child 2007;92:898-89.

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43. Kozlowska WJ, Bush A, Wade A, Aurora P, Carr SB, Castle RA, Hoo AF, Lum S, Price J, Ranganathan S, Saunders C, Stanojevic S, Stroobant J, Wallis C, Stocks J; London Cystic Fibrosis Collaboration*. Lung function from infancy to the preschool years after clinical diagnosis of cystic fibrosis. Am J Respir Crit Care Med 2008;178:42-9. * I am member of LCFC.

44. Regamey N, Balfour-Lynn I, Rosenthal M, Hogg C, Bush A, Davies JC. Time required to obtain endobronchial biopsies in children during fiberoptic bronchoscopy. Pediatr Pulmonol 2009;44:76-9.

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45. Balfour-Lynn IM, Welch K. Inhaled corticosteroids for cystic fibrosis. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD001915.

46. Kariholu U, Rawal J, Subramanian G, Balfour-Lynn IM, Sandhu G. An unusual case of wheeze. Arch Dis Child 2009;94:310.

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47. Bossley CJ, Saglani S, Kavanagh C, Payne DN, Wilson N, Tsartsali L, Rosenthal M, Balfour-Lynn IM, Nicholson AG, Bush A. Corticosteroid responsiveness and clinical characteristics in childhood difficult asthma. Eur Respir J 2009;34:1052-9.

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48. Heijerman H, Westerman E, Conway S, Touw D; Gerd Döring for the consensus working group. Inhaled medication and inhalation devices for lung disease in patients with cystic fibrosis: A European consensus. J Cyst Fibros 2009;8:295-315. * Member of consensus working group.

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49. Gupta A, Urquhart DS, Devaraj A, Balfour-Lynn IM. A 2 year old with fever and cough. BMJ 2009;339:b2150. doi: 10.1136/bmj.b2150.

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50. Balfour-Lynn IM, Field DJ, Gringras P, Hicks B, Jardine E, Jones RC, Magee AG, Primhak RA, Samuels MP, Shaw NJ, Stevens S, Sullivan C, Taylor JA, Wallis C; Paediatric Section of the Home Oxygen Guideline Development Group of the BTS Standards of Care Committee. BTS guidelines for home oxygen in children. Thorax 2009;64 Suppl 2:ii1-26.

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51. Cheung MS, Bridges NA, Prasad SA, Francis J, Carr SB, Suri R, Balfour-Lynn IM. Growth in children with cystic fibrosis-related diabetes. Pediatr Pulmonol 2009;44:1223-5.

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52. Aurora P, Stanojevic S, Wade A, Oliver C, Kozlowska W, Lum S, Bush A, Price J,Carr SB, Shankar A, Stocks J; on behalf of the London CF Collaboration*. Lung Clearance Index at 4 Years Predicts Subsequent Lung Function in Children with Cystic Fibrosis. Am J Respir Crit Care Med. 2011;183:752-58. * I am member of LCFC.

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53. Primhak RA, Hicks B, Shaw NJ, Donaldson GC, Balfour-Lynn IM. Use of home oxygen for children in England and Wales. Arch Dis Child. 2011;96:389-92.

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54. McKee AJ, Ives A, Balfour-Lynn IM. Increased incidence of bronchopulmonary fistulas complicating paediatric pneumonia. Pediatr Pulmonol 2011;46:717-21.

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55. Stafler P, Davies JC, Balfour-Lynn IM, Rosenthal M, Bush A. Bronchoscopy in cystic fibrosis infants diagnosed by newborn screening. Pediatr Pulmonol. 2011;46:696-7.

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56. Ahmedzai S, Balfour-Lynn IM, Bewick T, Buchdahl R, Coker RK, Cummin AR, Gradwell DP, Howard L, Innes JA, Johnson AO, Lim E, Lim WS, McKinlay KP, Partridge MR, Popplestone M, Pozniak A, Robson A, Shovlin CL, Shrikrishna D, Simonds A, Tait P, Thomas M; British Thoracic Society Standards of Care Committee. Managing passengers with stable respiratory disease planning air travel: British Thoracic Society recommendations. Thorax 2011;66 Suppl 1:i1-i30.

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57. Hoo AF, Thia LP, Nguyen TT, Bush A, Chudleigh J, Lum S, Ahmed D, Balfour-Lynn I, Carr SB, Chavasse RJ, Costeloe KL, Price J, Shankar A, Wallis C, Wyatt HA, Wade A, Stocks J; London Cystic Fibrosis Collaboration. Lung function is abnormal in 3-month-old infants with cystic fibrosis diagnosed by newborn screening. Thorax. 2012;67:874-81.58.

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58. Sharples J, Gupta A, Fleming L, Bossley CJ, Bracken-King M, Hall P, Hayward A, Puckey M, Balfour-Lynn I, Rosenthal M, Bush A, Saglani S. Long-term effectiveness of a staged assessment for paediatric problematic severe asthma. Eur Respir J 2012;40:264-7.

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59. Urquhart DS, Thia LP, Francis J, Prasad SA, Dawson C, Wallis C, Balfour-Lynn IM. Deaths in childhood from cystic fibrosis: 10-year analysis from two London specialist centres. Arch Dis Child 2013;98:123-7.

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60. Nguyen TT, Thia LP, Hoo AF, Bush A, Aurora P, Wade A, Chudleigh J, Lum S, Stocks J; on behalf of the London Cystic Fibrosis Collaboration (LCFC). Evolution of lung function during the first year of life in newborn screened cystic fibrosis infants. Thorax 2014;69:910-73. * I am member of LCFC.

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61. Thia LP, Calder A, Stocks J, Bush A, Owens CM, Wallis C, Young C, Sullivan Y, Wade A, McEwan A, Brody AS; on behalf of the London Cystic Fibrosis Collaboration (LCFC). Is chest CT useful in newborn screened infants with cystic fibrosis at 1 year of age? Thorax 2014;69:320-7. * I am member of LCFC.

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62. Lim MTC, Wallis C, Price JF, Carr SB, Chavasse RJ, Shankar A, Seddon P, Balfour-Lynn IM. Diagnosis of cystic fibrosis in the Pan-Thames Region before and after the introduction of newborn screening. Arch Dis Child 2014;99:197-202.

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63. Conway S, Balfour-Lynn IM, De Rijcke K, Drevinek P, Foweraker J, Havermans T, Heijerman H, Lannefors L, Lindblad A, Macek M, Madge S, Moran M, Morrison L, Morton A, Noordhoek J, Sands D, Vertommen A, Peckham D. European Cystic Fibrosis Society Standards of Care: Framework for the Cystic Fibrosis Centre. J Cyst Fibros 2014;13 S1:S3-S22.

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64. Grime CJ, Greenaway C, Clarke S, Balfour-Lynn IM. Critical timing of gastrostomy insertion in a child with cystic fibrosis. Paediatr Respir Rev 2015 Suppl 1:19-21.

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65. Balfour-Lynn IM, Welch K. Inhaled corticosteroids for cystic fibrosis. Cochrane Database Syst Rev. 2016 Aug 23;(8):CD001915.

66. Ratjen F, Hug C, Marigowda G, Tian S, Huang X, Stanojevic S, Milla CE, Robinson PD, Waltz D, Davies JC; VX14-809-109 investigator group. Efficacy and safety of lumacaftor and ivacaftor in patients aged 6-11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled phase 3 trial. Lancet Respir Med. 2017;5:557-567. *I was a member of Investigator Group.

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67. Edmondson C, Grime C, Prasad A, Cowlard J, Nwokoro CEC, Ruiz G, Wallis C, Balfour-Lynn IM. Cystic fibrosis newborn screening: outcome of infants with normal sweat tests. Arch Dis Child. 2018;103:753-6.

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68. Davies G, Stocks J, Thia LP, Hoo AF, Bush A, Aurora P, Brennan L, Lee S, Lum S, Cottam P, Miles J, Chudleigh J, Kirkby J, Balfour-Lynn IM, Carr SB, Wallis C, Wyatt H, Wade A; London Cystic Fibrosis Collaboration (LCFC). Pulmonary function deficits in newborn screened infants with cystic fibrosis managed with standard UK care are mild and transient. Eur Respir J. 2017; Nov 9;50(5). pii: 1700326. doi: 10.1183/13993003.00326-2017

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69. Wright MFA, Balfour-Lynn IM. Habit-tic cough: Presentation and outcome with simple reassurance. Pediatr Pulmonol 2018;53:512-6.

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70. Naqvi N, Doughty VL, Starling L, Franklin RC, Ward S, Daubeney PEF, Balfour-Lynn IM. Hypoxic Challenge Testing (Fitness to Fly) in children with complex congenital heart disease. Heart 2018;104:1333-8.

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71. Willson R, Makhecha S, Moore-Crouch R, Balfour-Lynn IM. Prescribing emergency oral steroids in asthma clinics. Arch Dis Child. 2019 Jun 11. pii:archdischild-2018-316609. doi:10.1136/archdischild-2018-316609. [Epub ahead of print].

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72. Balfour-Lynn IM, Welch K, Smith S. Inhaled corticosteroids for cystic fibrosis. Cochrane Database Syst Rev. 2019 Jul 4;7:CD001915. doi:10.1002/14651858.CD001915.pub6.

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73. Balfour-Lynn IM, Khan K, Pentayya N, Pheasant C, Bentley S, Makhecha S. Initiating Self-Administration of Medicines for inpatients with cystic fibrosis. Arch Dis Child 2020;105:986-90.

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74. Bentley S, Davies JC, Carr SB, Balfour-Lynn IM. Combination antifungal therapy for Scedosporium species in cystic fibrosis. Pediatr Pulmonol 2020;55:1993-5.2020;105:986-90.

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75. Seddon L, Dick K, Carr SB, Balfour-Lynn IM. Communicating cystic fibrosis newborn screening results to parents. Eur J Pediatr 2021;180:1313-6.

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76. Zimmels S, Balfour-Lynn IM, Christodoulou L, Pantazi M, Pavlidou E, Pitt M, Kinali M, Ismayilova N. Isolated bulbar palsy and dysphagia in children with respiratory symptoms. Dev Med Child Neurol. 2022;64:518-22

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77. Saglani S, Bingham Y, Balfour-Lynn I, Goldring S, Gupta A, Banya W, Moreiras J, Fleming L, Bush A, Rosenthal M. Blood eosinophils in managing preschool wheeze: Lessons learnt from a proof-of-concept trial. Pediatr Allergy Immunol. 2022 Jan;33(1):e13697.

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78. Xuereb J, Sammut P, Vella C, Balfour-Lynn IM. Resolution of lobe collapse in a child with cystic fibrosis with Mycobacterium abscessus using serial intrabronchial rhDNase. Pediatr Pulmonol. 2022 Mar 22. doi: 10.1002/ppul.25902. Epub ahead of print.

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